Tilda Publishing

ПЕРСПЕКТИВНЫЕ МАТЕРИАЛЫ

PERSPEKTIVNYE
MATERIALY

Tilda Publishing

ПЕРСПЕКТИВНЫЕ МАТЕРИАЛЫ

2025, № 9

ПЕРСПЕКТИВНЫЕ МАТЕРИАЛЫ

Calcium phosphate materials for osteoplasty and their prospects as anticancer drug delivery systems: A Review

N. A. Lebedeva, E. V. Galitsyna, N. V. Volkova, N. A. Ulyakina

In this paper we analyze the research and development in the field of calcium-phosphate materials for the replacement of bone tissue defects, including those with antitumor action - in the case of bone defects resulting from cancer diseases affecting and/or metastasizing to bone tissue. The following databases were used for the analysis: PubMed; Web of Science; The Lens; Espacenet; Information Search System of Federal Institute of Industrial Property (FIIP); digital platform “Rospatent”; Unified State Information System for Accounting of Research, Development and Technological Work of Civil Purpose (EGISU NIOKTR); electronic service of the Federal Service for Surveillance in Healthcare (Roszdravnadzor) — State Register of Medical Devices and Organisations (Individual Entrepreneurs) engaged in the production and manufacturing of medical devices (State Register of medical devices). According to the results of analysis of data in EGISU NIOKTR, the largest number of studies in the field of calcium-phosphate materials for replacement of bone tissue defects were started in Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences (Baikov Institute). A total of 81 research and development (R&D) works in this field are registered in the EGISU NIOKTR, of which only 16 % of the works are devoted to obtaining materials intended for the restoration of bone tissue defects and having therapeutic potential, including in the field of oncology. As a result of the analysis of patent documents contained in the above databases, we can conclude that Russian Federation has low patent activity in the field of creation and application of calcium-phosphate materials for replacement of bone tissue defects compared to other countries of the world. Among patent holders from Russia, Baikov Institute is in the first place by the number of patents. The analysis of State Register of medical devices shows that 25 medical devices representing calcium-phosphate materials for bone tissue defects replacement are registered on the Russian market, and 16 of them belong to manufacturers from Russia. At the same time, 7 registration certificates have been issued for calcium-phosphate materials, which additionally include active substances or medicinal preparations in their composition, and 5 of such materials belong to Russian organisations.

Keywords: calcium-phosphate materials, delivery of biologically active substances and medicines, oncology, research and development, patent activity, medical devices.

DOI: 10.30791/1028-978X-2025-9-5-21

Reference citing:
Lebedeva N.A., Galitsyna E.V., Volkova N.V., Ulyakina N.A. Kal'cij-fosfatnye materialy dlya osteoplastiki, perspektivy ih ispol'zovaniya v kachestve materialov-nositelej dlya mestnoj dostavki protivoopuholevyh sredstv: obzor nauchnyh razrabotok i issledovanij [Calcium phosphate materials for osteoplasty and their prospects as anticancer drug delivery systems: A Review]. Perspektivnye Materialy [Advanced Materials] (in Russ), 2025, no. 9, pp. 5 – 21. DOI: 10.30791/1028-978X-2025-9-5-21

ПЕРСПЕКТИВНЫЕ МАТЕРИАЛЫ

Synthesis and properties of compositional material based
on polyethylene, bismuth oxide and carbide boron

V. I. Pavlenko, G. G. Bondarenko, N. I. Cherkashina, D. S. Romanyuk

This article presents the results of the synthesis and study of the properties of composite material based on polyethylene, boron carbide (B₄C) and bismuth oxide (BI₂O₃). The method of manufacturing composite material included a joint cryogenic grinding of all components in a liquid nitrogen with further pressing. The influence of cryogenic grinding on the distribution of fillers in the composite has been studied and an assessment of the prospect of using this method is evaluated compared to the traditional methods of mixing the components of polymer composites. Studies of the finished composite were carried out using SEM analysis, IR Fouria of spectroscopy and X-ray-phase analysis. The strength characteristics of the composite material with a different content of fillers were measured. The results showed that the composition containing 55 mass is optimal. % polyethylene, 5 mass. % carbide boron and 40 mass. % bismuth oxide, which provides good strength balance. Cryogenic grinding provided an uniform distribution of aggregate particles in the matrix and improved the strength characteristics of the material. The composite showed stability to a temperature of 250 ° C and has high thermal properties, which makes it promising for use in space technologies that require materials with high heat resistance and radiation protection.

Keywords: polyethylene, composite, carbide boron, bismuth oxide, cryogenic grinding, IR-Fourier spectroscopy.

DOI: 10.30791/1028-978X-2025-9-22-31

Reference citing:
Sipyagina S.M., GolPavlenko V.I., Bondarenko G.G., Cherkashina N.I., Romanyuk D.S. Sintez i svojstva kompozicionnogo materiala na osnove polietilena, oksida vismuta i karbida bora. Perspektivnye materialy [Synthesis and properties of compositional material based on polyethylene, bismuth oxide and carbide boron]. Perspektivnye Materialy [Advanced Materials] (in Russ), 2025, no. 9, pp. 22 – 31. DOI: 10.30791/1028-978X-2025-9-22-31

ПЕРСПЕКТИВНЫЕ МАТЕРИАЛЫ

Studies of nonlinear chalcogenide crystals for the mid-IR network

S. I. Lobanov, P. G. Krinitsyn, A. F. Kurus, A. P. Eliseev, K. E. Korzhneva, A. A. Goloshumova, V. N. Vedenyapiya, A. Y. Tarasova, L. I. Isaenko

BaGa4Se7 (BGSe) crystals were grown vertically by Bridgman methods and their main properties were studied. The thermal conductivity values of the LiGaS2 (LGS) crystal have been clarified. The main defects have been identified using photoluminescence spectra, showing that annealing of BGSe crystals in a BaSe atmosphere leads to a strong weakening of the photoluminescence peak. On the problems of molecular design, a search is underway for new promising crystals for powerful laser systems. We have found and obtained an AgLiGa2Se4 crystal using the Bridgman method. The main physical parameters have been studied for it.

Keywords: crystal synthesis, crystal growth, optical spectroscopy.

DOI: 10.30791/1028-978X-2025-9-32-39

Reference citing:
Lobanov S.I., Krinitsyn P.G., Kurus A.F., Eliseev A.P., Korzhneva K.E., Goloshumova A.A., Vedenyapiya V.N., Tarasova A.Y., Isaenko L.I. Issledovaniya nelinejnyh kristallov hal'kogenidov dlya srednego IK-diapazona [Studies of nonlinear chalcogenide crystals for the mid-IR network]. Perspektivnye Materialy [Advanced Materials] (in Russ), 2025, no. 9, pp. 32 – 39. DOI: 10.30791/1028-978X-2025-9-32-39

ПЕРСПЕКТИВНЫЕ МАТЕРИАЛЫ

Fracture toughness of ceramic composites based on ZrB₂, TiB₂
and SiC with low-modulus h-BN inclusions

M. P. Lukyanets, A. S. Buyakov, I. A. Fotin, V. V. Shmakov, E. V. Abdulmenova,
M. A. Rudmin, S. P. Buyakova

In this paper, the structure and properties of ceramic composites (ZrB₂ – TiB₂ – SiC) – (h-BN) are investigated. In the (ZrB₂ – TiB₂ – SiC) – (h-BN) system, the substitutional solid solution of (Zr_0,83Ti_0,17)B₂ was formed, during the sintering process. The addition of low-modulus inclusions of hexagonal boron nitride (h-BN) provided an increase in fracture toughness (K_IC) and flexural strength (σ_f). The highest values of K_IC = 6.01 ± 0.09 MPa·m^1/2 and σ_f = 544 ± 8 MPa of ceramic composites (ZrB₂ – TiB₂ – SiC) – (h-BN) were achieved with the addition of 5 vol % h-BN. The addition of low-modulus h-BN inclusions into the high-modulus ceramic matrix (ZrB₂ – TiB₂ – SiC) ensured the dissipation of crack energy at relatively weak internal interfaces of the “matrix–inclusion” due to crack bifurcation (the Cook – Gordon mechanism). In the (ZrB₂ – TiB₂ – SiC) – (h-BN) system, a significant increase in K_IC of the studied composites is due to the action of two mechanisms: the Cook-Gordon mechanism and the stopping of cracks in the field of residual compressive stresses. It was found that as the volume content of h-BN increases, the contribution of the Cook-Gordon mechanism to the fracture toughness of ceramic composites (ZrB₂ – TiB₂ – SiC) – (h-BN) increases. However, a further increase in the h-BN content (over 5 vol %) leads to a significant decrease in the fracture toughness of ceramic composites (ZrB₂ – TiB₂ – SiC) – (h-BN).

Keywords: the Cook – Gordon mechanism, ceramic composite, (Zr,Ti)B₂ solid solution, h-BN, fracture toughness К_IC.

DOI: 10.30791/1028-978X-2025-9-40-50

Reference citing:
Lukyanets M.P., Buyakov A.S., Fotin I.A., Shmakov V.V., Abdulmenova E.V., Rudmin M.A., Buyakova S.P. Treshchinostojkost' keramicheskih kompozitov na osnove ZrB2, TiB2 i SiC s nizkomodul'nymi vklyucheniyami h-BN [Fracture toughness of ceramic composites based on ZrB₂, TiB₂ and SiC with low-modulus h-BN inclusions]. Perspektivnye Materialy [Advanced Materials] (in Russ), 2025, no. 9, pp. 40 – 50. DOI: 10.30791/1028-978X-2025-9-40-50

ПЕРСПЕКТИВНЫЕ МАТЕРИАЛЫ

Apatite foam spheres formed on open-pore calcium phosphate foam ceramics

V. K. Krut’ko, L. Yu. Maslova, O. N. Musskaya, A. I. Kulak

In the Simulated Body Fluid (SBF) model solution at pH 7.3, apatite foam spheres were formed on calcium phosphate foam ceramics consisting of β-/α-tricalcium phosphate and β-calcium pyrophosphate. The microporous structure of the calcium phosphate foam ceramics is formed by rounded conglomerates 2 – 10 μm in size with micropores 2 – 8 μm in diameter. Application of one layer of hydroxyapatite led to an increase in the size of the conglomerates to 30 μm and a decrease in the micropores to 1 μm. Application of the second layer of hydroxyapatite contributed to smoothing the surface of the foam ceramics, “healing” microcracks and forming a structure with a small amount of micropores. “Apatite foam” was formed on calcium phosphate foam ceramics with one or two layers of crystalline hydroxyapatite in the SBF model solution. The presence of crystalline hydroxyapatite induced the formation of a crystallochemically similar apatite according to the epitaxial principle. After keeping the foam ceramics in the SBF solution, the amount of β-tricalcium phosphate decreased to 60 %, β- calcium pyrophosphate to 5 %, and the phases of α- tricalcium phosphate to 22 % and apatite to 13 % were formed. Keeping the foam ceramics reinforced with one or two layers of hydroxyapatite in the SBF solution led to an increase in the content of hydroxyapatite and newly formed apatite to 32 – 38 % with an insignificant change in the content of α- tricalcium phosphate to 48 – 50 % and β- tricalcium phosphate to 14 – 18 %.

Keywords: calcium phosphate foam ceramics, hydroxyapatite, Simulated Body Fluid, biomimetic precipitation, apatite foam spheres, apatite foam.

DOI: 10.30791/1028-978X-2025-9-51-61

Reference citing:
Krut’ko V.K., Maslova L.Yu., Musskaya O.N., Kulak A.I. Apatitovye penosfery, sformirovannye na otkrytoporistoj kal'cijfosfatnoj penokeramike [Apatite foam spheres formed on open-pore calcium phosphate foam ceramics]. Perspektivnye Materialy [Advanced Materials] (in Russ), 2025, no. 9, pp. 51 – 61. DOI: 10.30791/1028-978X-2025-9-51-61

ПЕРСПЕКТИВНЫЕ МАТЕРИАЛЫ

Nanostructured hybrid powders based on zirconia and oxygen-free graphene – new raw materials for fine-grained ceramics

Е. А. Trusova, А. М. Afzal, S. V. Shevtsov, D. S. Nikitin, А. Nassyrbayev,
N. V. Petrakova, А. Yu. Teplova, M. G. Safronenko

Nanocomposites based on graphene and zirconia play an important role in the development and production of materials in demand in a wide range of technologies for the production of innovative materials for oxygen sensors, lithium-ion battery electrodes, catalysts, implants, solid oxide fuel cells, and electronic devices. The paper presents the results of a study covering a chain of successive processes: obtaining powders of graphene-containing nanostructured composites, characterizing their phase composition and morphology, sintering the resulting compositions by hot pressing, vacuum sintering, and spark plasma sintering, and comparative analysis of the microstructure of the obtained model ceramic samples. All the resulting ceramics consisted of stoichiometric monoclinic baddeleyite ZrO₂. Distinctive features of the ceramics obtained by spark plasma sintering were a high relative density of 98% and a layered grain structure. The main result of the study can be considered the fact that graphene-zirconia nanostructured powder composites synthesized by the proposed method are promising for obtaining dense fine-grained ceramics. However, due to their unique nanostructure of the initial powders, they require the development of special modes and technological approaches to sintering to achieve high density and other unique characteristics.

Keywords: graphene-zirconia nanostructured composites, hot pressing, vacuum sintering, spark plasma sintering.

DOI: 10.30791/1028-978X-2025-9-62-78

Reference citing:
Trusova Е.А., Afzal А.М., Shevtsov S.V., Nikitin D.S., Nassyrbayev А., Petrakova N.V., Teplova А.Yu., Safronenko M.G. Nanostrukturirovannye gibridnye poroshki na osnove ZrO2 i beskislorodnogo grafena — novye iskhodnye dlya melkozernistoj keramiki [Nanostructured hybrid powders based on zirconia and oxygen-free graphene – new raw materials for fine-grained ceramics]. Perspektivnye Materialy [Advanced Materials] (in Russ), 2025, no. 9, pp. 62 – 78. DOI: 10.30791/1028-978X-2025-9-62-78

ПЕРСПЕКТИВНЫЕ МАТЕРИАЛЫ

Estimation of gas pressure in closed pores by ultrasonic method

S. I. Averin, M. I. Alymov

A methodical approach to the study of gas pressure in closed pores of solids by ultrasonic scanning of the sample has been developed. It is proposed to take into account the property of non-perfection of gas in pores, which makes it possible to calculate the gas pressure in closed pores by a nondestructive method. The possibility of isolating the sound velocity in the pore from the total sound velocity in ultrasonic scanning is shown. The data of approximation of sound velocity as a function of pressure for various gases and gas mixtures are presented. The applicability of ultrasonic scanning for experimental determination of pressure in pores for different gases is evaluated.

Keywords: pressure in a pore, powder metallurgy, porosity, closed pores, gas-filled pores, sound velocity in porous, ultrasound method.

DOI: 10.30791/1028-978X-2025-9-79-86

Reference citing:
Averin S.I., Alymov M.I. Ocenka davleniya gaza v zakrytyh porah ul'trazvukovym metodom [Estimation of gas pressure in closed pores by ultrasonic method]. Perspektivnye Materialy [Advanced Materials] (in Russ), 2025, no. 9, pp. 79 – 86. DOI: 10.30791/1028-978X-2025-9-79-86